珠海市雙博杰科技有限公司

 
中文同義詞: 反-4-(氨甲基)環(huán)己烷甲酸;;氨甲基環(huán)己酸;抗血纖溶環(huán)酸;止血環(huán)酸;凝血酸雜質(zhì)C;反式-4-(氨甲基)環(huán)己烷甲酸;反式 
英文名稱: Amstat 
英文同義詞: TIMTEC-BB SBB006715;TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID;trans-4-aminomethylcyclohexane-1-carboxylate;TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID;TRANEXAMIC ACID;amstat;amcha;amikapron 
CAS號: 1197-18-8 
分子式: C8H15NO2 
分子量: 157.21 
EINECS號: 214-818-2 
    為的衍生物，是一種抗纖溶的止血藥物，止血機制與、相同，但作用更強，強度是的7～10倍、的2倍，而毒性相近。
化學(xué)結(jié)構(gòu)與賴氨酸相似，能競爭性阻抑纖溶酶原在纖維蛋白上吸附，防止其激活，保護纖維蛋白不被纖溶酶所降解和溶解，終達到止血效果。適用于治療急性或慢性、局限性或全身性原發(fā)性纖維蛋白溶解亢進所致的各種出血，如產(chǎn)科出血，出血、前列腺肥大出血、血友病、肺結(jié)核喀血、胃出血、肝、肺、脾等內(nèi)臟手術(shù)后的出血等；也可用于手術(shù)時異常出血等。
臨床上對蟲咬癥、濕疹皮炎、單純性紫癜、慢性蕁麻疹、人工性蕁麻疹、中毒疹和藥疹等效果顯著，對紅皮病、硬皮病、SLE、多形紅斑、帶狀皰疹和斑禿亦有一定療效，對遺傳性血管性水腫療效亦較好。治療黃褐斑一般用藥3周左右見效，5周顯效， 60 d一療程。每次口服0.25～0.5g，一日3～ 4次。少數(shù)患者可發(fā)生惡心、疲乏、瘙癢、腹部不適和腹瀉等副作用，停藥后癥狀即消失。
質(zhì)量標(biāo)準(zhǔn)：BP2010口服級
包裝：25KG 紙板桶

Tranexamic acid
Synonyms:4-(Aminomethyl)cyclohexanecarboxylic Acid (cis- and trans- mixture);4-(Aminomethyl)cyclohexanecarboxylic acid;Tranexamic acid
CAS:1197-18-8
MF:C8H15NO2
MW:157.21
EINECS:214-818-2
Product Categories:4-Substituted Cyclohexanecarboxylic Acids;Amines;Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds
Chemical Properties:White Solid
Assay:99%
Usage:Labelled Tranexamic Acid.Tranexamic acid (T714505) impurity.
Packing:25kg/drum 

Test Items Specification Test Results
Appearance White crystalline powder White crystalline powder
Solubility Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%) Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%)
Identification Infrared absorption map complies with the tranexamic acid comparison map Infrared absorption map complies with the tranexamic acid comparison map
 PH 7.0～8.0 7.24
Loss on drying ≤0.5% 0.09%
Residue on ignition ≤0.1% 0.01%
Heavy metals ≤10ppm ＜10ppm
Sulphate ash ≤0.1% ＜0.03%
Chloride ≤140ppm ＜140ppm
Assay 99.0%～101.0% 99.95%
 Related substances A≤0.1%, B≤0.2%                          C   ≤  0.1%,      D  ≤   0.1% Total impurities(except A,B) ≤0.2% A≤0.1%, B≤0.2%                          C    ≤  0.1%,    D   ≤  0.1% Total impurities(except A,B)=0.015%
Conclusion Complies with BP2012

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