山東新華制藥股份有限公司

6-氨基-1,3-二甲基尿嘧啶6-Amino-1,3-dimethyluracil(DMAU)

用途Application:

6-氨基-1,3-二甲基尿嘧啶(6-氨基-1,3-二甲基脲嘧啶)，用于API的合成，也廣泛用于PVC熱穩(wěn)定劑的原輔料；

6-Amino-1,3-dimethyluracil(DMAU),?in?pharmaceutical?industry,?use?it?in?synthesis?of?Theophylline?and?etc.;?

also?can be?widely?used?as?ingredient?for?PVC?heat?stabilizer;

簡(jiǎn)介Capacity：

該產(chǎn)品是我公司的主打產(chǎn)品之一，我公司為該產(chǎn)品大生產(chǎn)商，有歐盟REACH正式注冊(cè)；It?is?our?strong?product,?we?are?the?leading?manufacturer?of?it,?have?formal?EU-REACH?registration;

技術(shù)說明書Technical?Data?Sheet：

化學(xué)名：6-氨基-1,3-二甲基尿嘧啶(6-氨基-1,3-二甲基脲嘧啶)

Chemical?Name:?6-Amino-1,3-dimethyluracil(DMAU)

分子式Formula:?C6H9N3O2

分子量MW:?155.16

Cas#:?6642-31-5

結(jié)構(gòu)式Structure?Formula:

物理特性Physical?Properties:

顏色Color:?類白色到淡黃色粉末off-white?to?light?yellow?powder;

20degC下比重Specific?Gravity?at?20degC:?無N/A;

規(guī)格Specifications:

含量Assay:?大于99.0%?min.;

干燥失重loss?on?drying:?小于1%max.;

粒度Particle?size,?45μm:?大于99%min.;

包裝Packing:?25kgs塑編袋25kgs?plastic?woven?bag;

產(chǎn)品作用原理mechanism：

一、6-氨基-1,3-二甲基尿嘧啶（簡(jiǎn)稱DMAU）作用原理:

熔點(diǎn)高達(dá)290℃以上，200℃加熱減量＜1%，本身特性能夠適應(yīng)PVC生產(chǎn)過程。?DMAU能吸收PVC生產(chǎn)過程

中產(chǎn)生的HCl，還能取代不穩(wěn)定的Cl原子。與ZnSt2共同使用時(shí)，?DMAU能與ZnCl2發(fā)生反應(yīng)，生成金屬絡(luò)合

物，使ZnCl2失去活性，能防止“鋅燒”，大大增強(qiáng)PVC樣品的長(zhǎng)期穩(wěn)定性；DMAU中主要基團(tuán)尿嘧啶是人體

必需的四種核苷酸之一，對(duì)人體安全無害；DMAU因此被認(rèn)為是高效且安全的熱穩(wěn)定劑；

A.?Mechanism:

with?melting?point?of?more?than?290degC,?loss?on?drying?under?200degC?of?less?than?1%,?it?suits?for?

PVC’s?producing?process.?Can?absorb?HCl?which?is?by-produced?during?producing?process?of?PVC,?can?replace?Cl-?which?is?not?stable.?When?be?used?with?

ZnSt2,?can?react?with?ZnCl2?to?create?metal?complex,?then?ZnCl2?losses?its?activity,?so?can?avoid?PVC’s?

color?from?changing?into?darker,?improve?PVC’s?long?term?stability;?Its?basic?chemical?structure?‘uracil’?is?

one?of?the?essential?nucleotides?of?the?human?body,?has?no?hazardous?to?human;?So?it?is?taken?as?PVC?

heat?stabilizer?of?high-efficiency?and?safety;

二、DMAU與ZnSt2:

含有DMAU/ZnSt2復(fù)合穩(wěn)定劑，無論初期白度還是長(zhǎng)期穩(wěn)定性都比含有CaSt2/ZnSt2復(fù)合穩(wěn)定劑的更好。

DMAU與ZnSt2共同使用時(shí)具有良好的系統(tǒng)穩(wěn)定效果，比目前工業(yè)上常用的的協(xié)同效果更好；

B.?DMAU?and?ZnSt2:

Stabilizer?of?DMAU/ZnSt2?is?better?than?stabilizer?of?CaSt2/ZnSt2?on?both?initial?whiteness?and?long?term?

stability;?DMAU/ZnSt2?is?of?systematic?stability,?its?efficiency?is?better?than?that?of?CaSt2/ZnSt2,?which?is?

of?synergistic?stability;

三、?DMAU與水滑石（或沸石）:

DMAU與水滑石（或沸石，沸石更節(jié)省成本）同時(shí)使用，在鈣鋅穩(wěn)定劑的配方中，加入3-4%的DMAU和

8-10%的水滑石或沸石，能更好地抑制PVC初期著色度，該配方更加經(jīng)濟(jì)可靠；

C.?DMAU?and?Hydrotalcite(or?Aluminosilicate):

To?add?3-4%?of?DMAU?and?8-10%?hydrotalcite(or?Aluminosilicate,?whose?cost?is?lower)?into?Calcium/Zinc?stabilizer,?it?can?improve?

PVC’s?initial?colorless,?and?is?more?economic;

四、DMAU與β-二酮:

DMAU與β-二酮都是新興的有機(jī)穩(wěn)定劑，兩者單獨(dú)進(jìn)行比較，DMAU在抑制初期著色和長(zhǎng)期熱穩(wěn)定性方面

都能更勝一籌。實(shí)際生產(chǎn)過程中DMAU既可以完全替代β-二酮，也可以與β-二酮共同使用；

D.?DMAU?and?Stearoyl?benzoyl?methane:

DMAU?can?improve?PVC’s?initial?colorless?and?long?term?heat?stability,?so?is?Stearoyl?benzoyl?methane;

?when?preparing?PVC?stabilizer,?DMAU?can?replace?stearoyl?benzoyl?methane,?DMAU?can?be?used?together?

with?stearoyl?benzoyl?methane?also;

五、DMAU發(fā)展歷程:

DMAU應(yīng)用于PVC穩(wěn)定劑的技術(shù)早是由美國(guó)Chemtura研發(fā)，其將DMAU廣泛的應(yīng)用于其各種無鉛穩(wěn)定劑的

配方中。隨著對(duì)鉛鹽穩(wěn)定劑的限制，DMAU作為無鉛穩(wěn)定劑中的新星。新華制藥是國(guó)內(nèi)外大的DMAU

生產(chǎn)商。

E.?History?of?DMAU:

The?world?main?producers?of?PVC?stabilizer?are?cooperating?with?us.?Accompany?more?and?more?countries

?forbid?to?use?lead?salts?PVC?stabilizer,?it?will?be?used?more?and?more?widely;?We?are?the?leading?

manufacturer?of?DMAU.?